N-bromobutanimide → HCID 12703974, compound
Reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:13]=[C:12]([CH3:14])[CH:11]=[CH:10][N:9]=2)=[CH:4][CH:3]=1.[Br:15]N1C(=O)CCC1=O>>[Br:15][CH2:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:13]=[C:12]([CH3:14])[CH:11]=[CH:10][N:9]=2)=[CH:6][CH:7]=1Participants
3
Procedure
Reaction of this 2-(4-methylphenyl)-4-methylpyrimidine with N-bromosuccinimide, as described in Example 15, affords 2-(4-bromomethylphenyl)-4-methylpyrimidine with a melting point of 104°-106° C. after recrystallisation from ligroin. A mixture of 105 g of 2-(4-bromomethylphenyl)-4-methylpyrimidine and 265 g of triethylphosphite is slowly heated, with stirring, to 150° C., while simultaneously distilling off ethyl bromide, and then stirred for 5 hours at this temperature. After distilling off excess triethylphosphite, the phosphate is obtained in a yield of 125 g in the form of a light brown viscous oil.
Sources & evidence
- ORD record
- ord-3e75326c5bfe428d8dec091890146400
- Source dataset
- uspto-grants-1982_12
- Patent number
- US04366189
Reaction notes
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