反应详情

Pentafluoroaniline (17 g, 0.106 mol) is dissolved in 300 ml of toluene with heating. The 2-carbethoxyhydrazinecarbonyl chloride, 19.4 g (0.122 M) is added to the hot solution. The mixture is refluxed until a white solid precipitates. The solid is filtered to give 24.8 g. The product is crystallized by dissolving in ethyl acetate/toluene (1/2 by vol) and evaporating until crystals appear, mp 180°-182°.

1. temperaturewith heating
2. temperatureThe mixture is refluxed until a white solid
3. customprecipitates
4. filtrationThe solid is filtered
5. customto give 24.8 g
6. customThe product is crystallized
7. dissolutionby dissolving in ethyl acetate/toluene (1/2 by vol)
8. customevaporating until crystals