反应详情

0.3 ml of N-methyl-N-trimethylsilyltrifluoroacetamide (1.6 mmoles) was added at room temperature to a suspension of 354 mg (1.02 mmoles) of 3-methyl-7-phenylacetamido-3-cephem-4-carboxylic acid-1-oxide in 40 ml of o-dichlorobenzene and after stirring for 15 minutes, 20 ml of o-dichlorobenzene were added thereto. Bromination was carried out as described in Example 37 using 310 mg (1.74 mmoles) of N-bromosuccinimide as the brominating agent and irradiation was continued for 80 minutes to obtain trimethylsilyl 3-bromomethyl-7-phenylacetamido-3-cephem-4-carboxylate-1-oxide in a yield of 45%.

1. waitwas continued for 80 minutes