Sulfamic Acid → HCID 88683385, compound

Participants

Reaction Steps

325 mg (1.63 mmoles) of N-methyl-N-trimethylsilyltrifluoroacetamide were added at room temperature to a suspension of 280.7 mg (1.09 mmoles) of 7-formamido-3-methyl-3-cephem-4-carboxylic acid-1-oxide in 40 ml of dichloromethane and the mixture was stirred for half an hour, after which an almost clear solution was obtained. This was cooled in an ice-bath and 69.5 mg (0.71 mmole) of amidosulfonic acid were added to it. Bromination was carried out in half an hour using 275.8 mg (1.55 mmoles) of N-bromosuccinimide as the brominating agent to obtain a 52% yield of trimethylsilyl 3-bromomethyl-7-formamido-3-cephem-4-carboxylate-1-oxide.

Provenance & Evidence