Sulfamic Acid → HCID 88683385, compound

Participants

Reaction Steps

A suspension of 357.6 mg (1.39 mmoles) of 7-formamido-3-methyl-3-cephem-4-carboxylic acid-1-oxide in 40 ml of dichloromethane was heated to reflux and 359 mg (1.94 mmoles) of N-trimethylsilylcaprolactam were added thereto to obtain a clear, colorless solution within 3 minutes. This was cooled in an ice-bath and 100 mg (1.02 mmoles) of amidosulfonic acid were added. Bromination was carried out in half an hour using 301.3 mg (1.69 mmoles) of N-bromosuccinimide as the brominating agent to obtain a 62% yield of trimethylsilyl 3-bromomethyl-7-formamido-3-cephem-4-carboxylate-1-oxide.

Provenance & Evidence