反应详情

温度

40 °C

207 mg (0.86 mmoles) of trimethylsilyl trimethylsilylamidosulfonate were added to a suspension of 353 mg (1.06 mmoles) of 7-benzamido-3-methyl-3-cephem-4-carboxylic acid-1-oxide in 25 ml of dichloromethane and the mixture was stirred at 40° C. for 3 hours. The colorless translucent suspension was cooled in an ice-bath and bromination was carried out in half an hour using 277 mg of N-bromosuccinimide (1.56 mmoles) as the brominating agent to obtain a 49% yield of trimethylsilyl 7-benzamido-3-bromomethyl-3-cephem-4-carboxylate-1-oxide.

1. temperatureThe colorless translucent suspension was cooled in an ice-bath
2. waitbromination was carried out in half an hour