反应详情

To a suspension of 335 mg (1.00 mmole) of 7-benzamido-3-methyl-3-cephem-4-carboxylic acid-1-oxide in 25 ml of dichloromethane, 279 mg of N-methyl-N-trimethylsilyltrifluoroacetamide (1.40 mmoles) were added and the mixture was stirred for 10 minutes at room temperature to obtain a clear, yellow solution. This was cooled in an ice-bath and bromination was carried out in half an hour using 253 mg of N-bromosuccinimide (1.42 mmoles) as the brominating agent to obtain a yield of 52% of trimethylsilyl 7-benzamido-3-bromomethyl-3-cephem-4-carboxylate-1-oxide.

1. additionwere added
2. customto obtain a clear, yellow solution
3. temperatureThis was cooled in an ice-bath
4. waitbromination was carried out in half an hour