N-bromobutanimide → HCID 70463777, compound

Participants

Reaction Steps

A mixture consisting of 753 mg (2.16 mmoles) of 3-methyl-7-phenylacetamido-3-cephem-4-carboxylic acid-1-oxide, 785 mg (4.94 mmoles) of N-trimethylsilyl-2-oxazolidinone and 70 ml of dichloromethane was refluxed for 2 hours, after which a clear, almost colorless solution was obtained. This was cooled in an ice-bath and bromination was carried out in half an hour using 624.5 mg (3.51 mmoles) of N-bromosuccinimide as the brominating agent to obtain a yield of 48% of trimethylsilyl 3-bromomethyl-7-phenylacetamido-3-cephem-4-carboxylate-1-oxide.

Provenance & Evidence