反应详情

263.4 mg of 3-methyl-7-phenylacetamido-3-cephem-4-carboxylic acid-1-oxide (0.76 mmoles) were added to a solution of 256 mg (1.08 mmoles) of N-trimethylsilyl-4-nitrobenzamide in 50 ml of dichloromethane and the clear solution that was obtained after refluxing this mixture for one hour was cooled in an ice-bath. Bromination was carried out in half an hour using 194.4 mg (1.09 mmoles) of N-bromosuccinimide as the brominating agent and some precipitate was formed after 20 minutes irradiation to obtain a 44% yield of trimethylsilyl 3-bromomethyl-7-phenylacetamido-3-cephem-4-carboxylate-1-oxide.

1. customthe clear solution that was obtained
2. temperatureafter refluxing this mixture for one hour
3. temperaturewas cooled in an ice-bath
4. waitBromination was carried out in half an hour
5. customsome precipitate was formed after 20 minutes
6. customirradiation