N-bromobutanimide → HCID 70463777, compound

Participants

Reaction Steps

355.9 mg (2.06 mmoles) of N-trimethylsilyl-2,2-dimethylpropanamide were added to a suspension of 426.0 mg (1.22 mmoles) of 3-methyl-7-phenylacetamido-3-cephem-4-carboxylic acid-1-oxide in a mixture of 40 ml of dichloromethane and 2 ml of nitrobenzene and the mixture obtained was refluxed for one hour. The clear solution obtained was cooled in an ice-bath and bromination was carried out in half an hour using 336.6 mg (1.89 mmoles) of N-bromosuccinimide as the brominating agent to obtain a 44% yield of trimethylsilyl 3-bromomethyl-7-phenylacetamido-3-cephem-4-carboxylate-1-oxide.

Provenance & Evidence