Sulfamic Acid → HCID 70463777, compound

Participants

Reaction Steps

380.7 mg (1.09 mmoles) of 3-methyl-7-phenylacetamido-3-cephem-4-carboxylic acid-1-oxide were silylated by refluxing in 60 ml of dichloromethane with 320.5 mg (1.85 mmoles) of N-trimethylsilyl-2,2-dimethylpropanamide for half an hour. After the addition of 0.1 g (1 mmole) of amidosulfonic acid, the clear, slightly yellow solution was cooled in an ice-bath and bromination was carried out in half an hour using 291.4 mg (1.64 mmoles) of N-bromosuccinimide as the brominating agent to obtain a 44% yield of trimethylsilyl 3-bromomethyl-7-phenylacetamido-3-cephem-4-carboxylate-1-oxide.

Provenance & Evidence