N-bromobutanimide → HCID 70463777, compound

Participants

Reaction Steps

352 mg (1.01 mmoles) of 3-methyl-7-phenylacetamido-3-cephem-4-carboxylic acid-1-oxide were silylated in 40 ml of chloroform at 60° C. in half an hour with 0.28 g (1.8 mmoles) of N-trimethylsilyl-2,2-dimethylpropanamide and the clear, pale yellow solution obtained was cooled in an ice-bath. Bromination was carried out in half an hour using 0.24 g (1.35 mmoles) of N-bromosuccinimide as the brominating agent to obtain a 40% yield of trimethylsilyl 3-bromomethyl-7-phenylacetamido-3-cephem-4-carboxylate-1-oxide.

Provenance & Evidence