N-bromobutanimide → HCID 70463777, compound

Participants

Reaction Steps

The clear solution that was obtained after refluxing a mixture of 357 mg (1.02 mmoles) of 3-methyl-7-phenylacetamido-3-cephem-4-carboxylic acid-1-oxide, 50 ml of chloroform and 2 ml (about 10 mmoles) of N-trimethylsilylsuccinimide for one and a half hours was cooled in an ice-bath. Bromination was carried out in half an hour using 0.24 mg (1.35 mmoles) of N-bromosuccinimide as the brominating agent to obtain a 42% yield of trimethylsilyl 3-bromomethyl-7-phenylacetamido-3-cephem-4-carboxylate-1-oxide.

Provenance & Evidence