Sulfamic Acid → HCID 70463777, compound

Participants

Reaction Steps

601.5 mg (1.73 mmoles) of 3-methyl-7-phenylacetamido-3-cephem-4-carboxylic acid-1-oxide were silylated by refluxing in 50 ml of dichloromethane for one hour with 503 mg (2.61 mmoles) of N-trimethylsilylbenzamide. 0.1 g of amidosulfonic acid (1 mmole) were added to the clear, slightly yellow solution obtained and after cooling in an ice-bath, bromination was carried out in half an hour with 464.8 mg (2.61 mmoles) of N-bromosuccinimide to obtain a yield of 42% of trimethylsilyl 3-bromomethyl-7-phenylacetamido-3-cephem-4-carboxylate-1-oxide.

Provenance & Evidence