Sulfamic Acid → HCID 70463777, compound

Participants

Reaction Steps

The clear solution obtained after refluxing a mixture consisting of 40 ml of dichloromethane, 608.7 mg (1.75 mmoles) of 3-methyl-7-phenylacetamido-3-cephem-4-carboxylic acid-1-oxide and 450 mg (2.83 mmoles) of N-trimethylsilyl-2-oxazolidinone for two hours was cooled in an ice-bath and 0.1 g of amidosulfonic acid (1 mmole) was added thereto. Bromination was carried out in half an hour using 469 mg (2.63 mmoles) of N-bromosuccinimide as the brominating agent to obtain a 46% yield of trimethylsilyl 3-bromomethyl-7-phenylacetamido-3-cephem-4-carboxylate-1-oxide.

Provenance & Evidence