Sulfamic Acid → HCID 70463777, compound

Participants

Reaction Steps

0.1 mg (1 mmole) of amidosulfonic acid was added to the clear solution obtained by refluxing 75 ml of dichloromethane containing 0.76 g (3.3 mmoles) of N-trimethylsilylbenzenesulfonamide and 350 mg (1.0 mmole) of 3-methyl-7-phenylacetamido-3-cephem-4-carboxylic acid-1-oxide for one and a half hours and the mixture obtained was cooled in an ice-bath. Bromination was carried out in one hour with 0.26 g (1.46 mmoles) of N-bromosuccinimide as the brominating agent to obtain a 40% yield of trimethylsilyl 3-bromomethyl-7-phenylacetamido-3-cephem-4-carboxylate-1-oxide.

Provenance & Evidence