Phosphorus oxychloride → HCID 178524399, compound

Participants

Reaction Steps

A solution of 2-[2-(2,2,2-trifluoroacetamido)thiazol-4-yl]-2-cyclopentyloxyiminoacetic acid (syn isomer, 1.6 g.), dry N,N-dimethylformamide (0.4 g.), phosphoryl chloride (0.8 g.), dry ethyl acetate (1.6 ml.) and tetrahydrofuran (20 ml.), and a solution of 7-amino-3-[1-(2-hydroxyethyl)-1H-tetrazol-5-yl-thiomethyl]-3-cephem-4-carboxylic acid (1.5 g.), trimethylsilylacetamide (3.8 g.) and dry ethyl acetate (30 ml.) were treated in a similar manner to that of Example 1-(1) to give 7-[2-[2-(2,2,2-trifluoroacetamido)thiazol-4-yl]-2-cyclopentyloxyiminoacetamido]-3-[1-(2-hydroxyethyl)-1H-tetrazol-5-ylthiomethyl]-3-cephem-4-carboxylic acid (syn isomer, 2.63 g.).

Provenance & Evidence