Water → HCID 178508492, compound

Participants

Reaction Steps

A solution of 7-[2-[2-(2,2,2-trifluoroacetamido)-thiazol-4-yl]-2-cyclopentyloxyiminoacetamido]-3-[1-(2-hydroxyethyl)-1H-tetrazol-5-ylthiomethyl]-3-cephem-4-carboxylic acid (syn isomer, 2.5 g.), sodium acetate 3 hydrate (4.9 g.), water (30 ml.) and tetrahydrofuran (14.0 ml.) was stirred at room temperature for 18 hours. After removing tetrahydrofuran from the resultant solution in vacuo, water (20 ml.) was added to the residue and adjusted to pH 3.0 with 10% hydrochloric acid. The precipitates were collected by filtration, washed with water and dried over phosphorus pentoxide to give 7-[2-(2-aminothiazol-4-yl)-2-cyclopentyloxyiminoacetamido]-3-[1-(2-hydroxyethyl)-1H-tetrazol-5-ylthiomethyl]-3-cephem-4-carboxylic acid (syn isomer, 1.54 g.), mp. 150°-156° C. (dec.).

Provenance & Evidence