Chloroacetyl chloride → HCID 54028900, compound

Participants

Reaction Steps

To a suspension of 14 g. (0.045 moles) of diethyl N-(2-ethoxycarbonylethyl)-amino-malonate hydrochloride prepared according to Example 1b) in 150 ml. of dry benzene 5.65 g. (4 ml., 0.05 moles) of chloroacetyl chloride are added with stirring. The mixture is boiled for 5 hours. The solution is evaporated in vacuo, the evaporation residue is triturated with 50 ml. of hexane, hexane is decanted and the same procedure is repeated two more times. The oily product is dried over sodium hydroxide in a vacuum desiccator. 13.6 g. (86%) of the named compound are obtained.

Provenance & Evidence