Water → HCID 20467711, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 9.5 g. (30 mmoles) of crude diethyl 1-(2-ethoxycarbonylethyl)-4-oxo-2,2-azetidine-dicarboxylate in 10 ml. of dimethyl sulfoxide 2.11 g. (36 mmoles) of sodium chloride and 1.1 ml. (60 mmoles) of water are added and the mixture is stirred for 9 hours at an oil bath of 180° C. The reaction mixture is poured on 200 ml. saturated aqueous hydrochloric acid solution and extracted with five 60-ml. portions of ether. The ethereal extract is dried with magnesium sulfate, filtered and the filtrate is evaporated in vacuo.

Provenance & Evidence