Triethylamine → HCID 54054830, compound

Participants

Reaction Steps

1.6 g. (8 mmoles) of 1-(2-ethoxycarbonylethyl)-4-(hydroxymethyl)-2-azetidinone prepared according to Example 5 are dissolved in 50 ml. of dry benzene, whereupon 2.2 ml. (1.16 g, 16 mmoles) of triethylamine are added to the solution, followed by a dropwise addition of 1.2 ml. (1.8 g., 16 mmoles) of mesyl chloride at 0° C., with stirring. After 30 minutes the salt is filtered off and the filtrate is evaporated in vacuo. The evaporation residue is dissolved in 50 ml. of chloroform, the solution is shaken with two 10-ml. portions of a 10% aqueous sodium carbonate solution and subsequently with three 10-ml. portions of water. The chloroform phase is dried over magnesium sulfate, filtered and the filtrate is evaporated. 1.9 g. (85%) of the named compound are obtained.

Provenance & Evidence