HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-Methoxy-11-methyldibenz(b,f)oxazepine-8-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 13277337 | HCID 13277337 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-Methoxy-11-methyldibenz(b,f)oxazepine-8-carboxylate | HCID 146138 | 92.3% |
Reaction Steps
A mixture of 1 g of ethyl 11-methyl-3-methoxydibenz-[b,f][1,4]oxazepine-8-carboxylate, 10 ml of methanol and 10 ml of 1 N aqueous sodium hydroxide was refluxed for 1 hour. After cooling, the mixture was neutralized with diluted hydrochloric acid, and the precipitating crystal was filtered off and recrystallized from methanol to give 0.84 g of 11-methyl-3-methoxydibenz[b,f][1,4]oxazepine-8-carboxylic acid. Yield 92%, m.p. 247° C. (with decomposition).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04435391 |
| Source dataset | uspto-grants-1984_03 |
| ORD ID | ord-a8cddfe0071e449887b7b6303b6dd970 |
| Source note | uspto-grants-1984_03 |