Prednisolone → HCID 13135587, compound

HRID 1903056Notes

Reaction equation

[OH:1][C@H:2]1[CH2:22][C@@:21]2([CH3:23])[C@@H:13]([CH2:14][CH2:15][C@:16]2([OH:24])[C:17](=[O:20])[CH2:18][OH:19])[C@H:12]2[C@H:3]1[C@:4]1([CH3:26])[C:9]([CH2:10][CH2:11]2)=[CH:8][C:7](=[O:25])[CH:6]=[CH:5]1.[CH3:27][O:28][CH2:29][CH2:30][C:31](Cl)=[O:32]>>[OH:1][C@H:2]1[CH2:22][C@@:21]2([CH3:23])[C@@H:13]([CH2:14][CH2:15][C@:16]2([OH:24])[C:17](=[O:20])[CH2:18][O:19][C:31](=[O:32])[CH2:30][CH2:29][O:28][CH3:27])[C@H:12]2[C@H:3]1[C@:4]1([CH3:26])[C:9]([CH2:10][CH2:11]2)=[CH:8][C:7](=[O:25])[CH:6]=[CH:5]1

Participants

Reactant 2

HCID 5755Prednisolone

HCID 27597283-Methoxypropanoyl chloride

Product 1

HCID 13135587HCID 13135587, compound

Procedure

Under the conditions of Example 3(a), 10.0 g of 11β,17,21-trihydroxy-1,4-pregnadiene-3,20-dione is reacted with 3-methoxypropionic acid chloride, worked up, and purified, thus isolating 7.3 g of 11β,17-dihydroxy-21-(3-methoxypropionyloxy)-1,4-pregnadiene-3,20-dione.

Workup

custompurified

Sources & evidence

ORD record: ord-e6acbd5bae63433b8ec3adce047c073f
Source dataset: uspto-grants-1984_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04435390

Reaction notes

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