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Methylprednisolone → 11beta,17-Dihydroxy-6alpha-methyl-21-(3-methoxypropionyloxy)-1,4-pregnadiene-3,20-dione
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methylprednisolone | HCID 6741 | — |
| 反応物 | 3-Methoxypropanoyl chloride | HCID 2759728 | — |
| 生成物 | 11beta,17-Dihydroxy-6alpha-methyl-21-(3-methoxypropionyloxy)-1,4-pregnadiene-3,20-dione | HCID 56620293 | — |
反応手順
Under the conditions of Example 3(a), 15.0 g of 11β,17,21-trihydroxy-6α-methyl-1,4-pregnadiene-3,20-dione is reacted with 3-methoxypropionic acid chloride, worked up, and purified, thus isolating 14.3 g of 11β,17-dihydroxy-6α-methyl-21-(3-methoxypropionyloxy)-1,4-pregnadiene-3,20-dione, mp 230° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04435390 |
| 出典データセット | uspto-grants-1984_03 |
| ORD ID | ord-798436e653864e28a3f8301899f6db16 |
| 出典メモ | uspto-grants-1984_03 |