Acetic Anhydride → HCID 13135610, compound

HRID 1903060Notes

Reaction equation

[OH:1][C@H:2]1[CH2:22][C@@:21]2([CH3:23])[C@@H:13]([CH2:14][CH2:15][C@:16]2([O:24][C:25](=[O:30])[CH2:26][CH2:27][O:28][CH3:29])[C:17](=[O:20])[CH2:18][OH:19])[C@H:12]2[C@H:3]1[C@:4]1([CH3:33])[C:9]([C@@H:10]([CH3:31])[CH2:11]2)=[CH:8][C:7](=[O:32])[CH:6]=[CH:5]1.[C:34](OC(=O)C)(=[O:36])[CH3:35]>>[C:34]([O:19][CH2:18][C:17](=[O:20])[C@:16]1([O:24][C:25](=[O:30])[CH2:26][CH2:27][O:28][CH3:29])[C@:21]2([CH3:23])[C@H:13]([C@H:12]3[C@H:3]([C@@H:2]([OH:1])[CH2:22]2)[C@:4]2([CH3:33])[C:9](=[CH:8][C:7](=[O:32])[CH:6]=[CH:5]2)[C@@H:10]([CH3:31])[CH2:11]3)[CH2:14][CH2:15]1)(=[O:36])[CH3:35]

Participants

Reactant 2

HCID 7918Acetic Anhydride

HCID 13135608HCID 13135608, compound

Product 1

HCID 13135610HCID 13135610, compound

Procedure

2.0 g of 11β,21-dihydroxy-17-(3-methoxypropionyloxy)-6α-methyl-1,4-pregnadiene-3,20-dione is reacted analogously to Example 5(c) with acetic anhydride, worked up, and purified, thus isolating 1.36 g of 21-acetoxy-11β-hydroxy-17-(3-methoxypropionyloxy)-6α-methyl-1,4-pregnadiene-3,20-dione, mp 162° C.

Workup

custompurified

Sources & evidence

ORD record: ord-f307212e0a0249bda729b3c7b58c2d01
Source dataset: uspto-grants-1984_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04435390

Reaction notes

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