HRID1903061

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：C[C@H]1C[C@@H]2[C@H]([C@@H](O)C[C@@]3(C)[C@H]2CC[C@]3(O)C(=O)CO)[C@@]2(C)C=CC(=O)C=C12

HCID6741

Methylprednisolone

C22H30O5

HCID12425341

3-Ethoxypropanoyl chloride

C5H9ClO2

PRODUCTS

生成物

结构：CCOCCC(=O)OCC(=O)[C@@]1(O)CC[C@H]2[C@@H]3C[C@H](C)C4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@@]21C

HCID13135589

未命名化合物

PROCEDURE

实验过程

15.0 g of 11β,17,21-trihydroxy-6α-methyl-1,4-pregnadiene-3,20-dione is reacted analogously to Example 4(a) with 3-ethoxypropionic acid chloride, worked up, and purified, thus isolating 13.6 g of 21-(3-ethoxypropionyloxy)-11β,17-dihydroxy-6α-methyl-1,4-pregnadiene-3,20-dione, mp 186° C.

WORKUP

后处理

custompurified