Epichlorohydrin → HCID 13305200, compound

HRID 1903073Notes

Reaction equation

[C:1]1([OH:11])[C:10]2[CH2:9][CH2:8][CH:7]=[CH:6][C:5]=2[CH:4]=[CH:3][CH:2]=1.[CH2:12]([CH:14]1[O:16][CH2:15]1)Cl.[OH-].[Na+]>>[O:16]1[CH2:15][CH:14]1[CH2:12][O:11][C:1]1[C:10]2[CH2:9][CH2:8][CH:7]=[CH:6][C:5]=2[CH:4]=[CH:3][CH:2]=1

Participants

Reactant 3

HCID 7835Epichlorohydrin

HCID 14798Sodium Hydroxide

HCID 115718247,8-dihydro-naphthalen-2-ol

Product 1

HCID 13305200HCID 13305200, compound

Procedure

7,8-Dihydro-α-naphthol prepared from 5-hydroxy-α-tetralone is allowed to react with epichlorohydrin in an aqueous solution of sodium hydroxide to give 1-(2,3-epoxypropoxy)-7,8-dihydronaphthalene [cf. J. Med. Chem. 21, 913 (1978)].

Sources & evidence

ORD record: ord-43c64d23bb924045b92a94bfe3f06914
Source dataset: uspto-grants-1984_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04435397

Reaction notes

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