Epichlorohydrin → 4-(oxiran-2-ylmethoxy)-1H-indole

HRID 1903076Notes

Reaction equation

[OH:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[CH:5][NH:6]2.[CH2:11]([CH:13]1[O:15][CH2:14]1)Cl>>[O:15]1[CH2:14][CH:13]1[CH2:11][O:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[CH:5][NH:6]2

Participants

Reactant 2

HCID 7835Epichlorohydrin

HCID 754211H-indol-4-ol

Product 1

HCID 6050154-(oxiran-2-ylmethoxy)-1H-indole

Procedure

4-Hydroxy indole is allowed to react with epichlorohydrin to give 4-(2,3-epoxypropoxy)indole, (cf. Netherlands Pat. No. 6,601,040).

Sources & evidence

ORD record: ord-f031dd2503d540d38e091af2489abcac
Source dataset: uspto-grants-1984_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04435397

Reaction notes

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