HuagongsheHuagongshe Chemistry Print Report · For research reference only
Epichlorohydrin → 5-[(Oxiran-2-yl)methoxy]-3,4-dihydroquinolin-2(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Epichlorohydrin | HCID 7835 | — |
| Reactant | 3,4-Dihydro-5-hydroxy-2(1H)-quinolinone | HCID 169153 | — |
| Product | 5-[(Oxiran-2-yl)methoxy]-3,4-dihydroquinolin-2(1H)-one | HCID 12899423 | — |
Reaction Steps
5-Hydroxy-3,4-dihydro-2-quinoline (prepared in three steps from cyclohexane-1,3-dione and acrylonitrile) is allowed to react with epichlorohydrin to give 5-(2,3-epoxypropoxy)-3,4-dihydro-2-quinolinone [J. Med. Chem. 17,529 (1974)].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04435397 |
| Source dataset | uspto-grants-1984_03 |
| ORD ID | ord-658d4f8f2a8741f685d328a753c524a7 |
| Source note | uspto-grants-1984_03 |