反应详情

2-Chloro-4-(4-formylpiperazino)pyrimidine (5.0 g) and dimethylamine (7.8 ml, 33% solution in ethanol) in ethanol (70 ml) were heated under reflux for 8 hours. The solvent was evaporated in vacuo and the residue was partitioned between chloroform and water. The aqueous layer was extracted twice with chloroform and the combined chloroform layers dried (Na2SO4) and evaporated in vacuo. The residue was re-crystallized from ethyl acetate to give 2-dimethylamino-4-(4-formylpiperazino)pyrimidine (2.7 g), m.p. 116° C.

1. temperatureunder reflux for 8 hours
2. customThe solvent was evaporated in vacuo
3. customthe residue was partitioned between chloroform and water
4. extractionThe aqueous layer was extracted twice with chloroform
5. dry with materialthe combined chloroform layers dried (Na2SO4)
6. customevaporated in vacuo
7. customThe residue was re-crystallized from ethyl acetate