HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Aminopyridine → beta-Oxo-alpha-(3-pyridylcarbamoyl)-beta-(1-methyl-2-pyrrolyl)propionitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Aminopyridine | HCID 10009 | — |
| Reactant | 1-Methyl-beta-oxo-alpha-ethoxycarbonyl-2-pyrrolepropionitrile | HCID 20285413 | — |
| Solvent | O-Xylene | HCID 7237 | — |
| Product | beta-Oxo-alpha-(3-pyridylcarbamoyl)-beta-(1-methyl-2-pyrrolyl)propionitrile | HCID 86739305 | — |
Reaction Steps
The mixture of 1.1 g of 1-methyl-β-oxo-α-ethoxycarbonyl-2-pyrrolepropionitrile (U.S. Pat. No. 4,256,759), 1.2 g of 3-aminopyridine and 60 ml of xylene, is refluxed for 41/2 hours. After standing and cooling to room temperature overnight, the solution is filtered, evaporated and the residue is purified to yield β-oxo-α-(3-pyridylcarbamoyl)-β-(1-methyl-2-pyrrolyl)propionitrile.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04435407 |
| Source dataset | uspto-grants-1984_03 |
| ORD ID | ord-79acfad9dbfa433dbc1a80ea52ec74db |
| Source note | uspto-grants-1984_03 |