Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Chlorotrimethylsilane | HCID 6397 | — |
| Reactant | HCID 13041786 | HCID 13041786 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 70424592 | HCID 70424592 | — |
Reaction Steps
A suspension of 1.5 g of 4-methoxymethyl-beta-carboline-3-carboxylic-acid-ethylester, 20 ml of acetonitrile, 3.1 g of sodium iodide and 2.7 ml of trimethylchlorosilane is stirred at 60° C. for 2 h. After cooling, it is poured into ice water and extracted with ethyl acetate. The extracts are washed with saturated sodium thiosulfate solution, dried and concentrated. 1.65 g of 4-iodo-methyl-beta-carboline-3-carboxylic-acid-methylester with a m.p. of 280°-286° C. is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04435403 |
|---|
| Source dataset | uspto-grants-1984_03 |
|---|
| ORD ID | ord-a09bdfce7fb94d089e727100d33c3390 |
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| Source note | uspto-grants-1984_03 |
|---|
