HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1903115Generated: October 31, 2026
Triethylamine → 6-Diethoxyphosphoryl-beta-carboline-3-carboxylic-acid-ethylester
https://huagongshe.com/reaction/1903115
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Diethylphosphite | HCID 3780918 | — |
| Reactant | ethyl 6-iodo-9H-pyrido[3,4-b]indole-3-carboxylate | HCID 13037317 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | 6-Diethoxyphosphoryl-beta-carboline-3-carboxylic-acid-ethylester | HCID 13136239 | 28.1% |
Reaction Steps
1.46 g of 6-iodo-beta-carboline-3-carboxylic-acid-ethylester is added anhydrously to a mixture of 608 g of diethylphosphite, 448 g of triethylamine, 240 mg of palladium tetrakristriphenylphosphine and 60 ml of N-methyl-2-pyrrolidone and is stirred for 12 h at 90° C. After concentration is an oil pump vacuum, the residue is chromatographed on 75 g of silica gel with methylene-chloride/acetone in the ratio of 1/1 as the eluant. The corresponding consolidated fractions are chromatographed on 25 g of silica gel with methylene-chloride/ethanol=10/2 as the eluant. 421 mg of 6-diethoxyphosphoryl-beta-carboline-3-carboxylic-acid-ethylester in the form of an oil is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04435403 |
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| Source dataset | uspto-grants-1984_03 |
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| ORD ID | ord-71248a9906a94fd99d49915d3f713d54 |
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| Source note | uspto-grants-1984_03 |
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