Thionyl Chloride → HCID 13136250, compound

HRID 1903118Notes

Reaction equation

HRID 1903118 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[N:7]=[CH:8][C:9]2[NH:10][C:11]3[C:16]([C:17]=2[CH:18]=1)=[CH:15][C:14]([C:19]#[C:20][CH2:21]O)=[CH:13][CH:12]=3)=[O:5])[CH3:2].S(Cl)([Cl:25])=O>>[CH2:1]([O:3][C:4]([C:6]1[N:7]=[CH:8][C:9]2[NH:10][C:11]3[C:16]([C:17]=2[CH:18]=1)=[CH:15][C:14]([C:19]#[C:20][CH2:21][Cl:25])=[CH:13][CH:12]=3)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 13136246HCID 13136246, compound

Product 1

HCID 13136250HCID 13136250, compound

Procedure

78 mg of 6-(3-hydroxy-1-propinyl)-beta-carboline-3-carboxylic-acid-ethylester in 2 ml of thionyl chloride is stirred for 3 h at room temperature. After evaporating till dry, the mixture is heated in ethanol and evacuated. By recrystallization from acetic-acid/cyclohexane, 40 mg of 6-(3-chloro-1-propinyl)-beta-carboline-3-carboxylic-acid-ethylester is obtained.

Workup

  1. customAfter evaporating
  2. customtill dry
  3. temperaturethe mixture is heated in ethanol
  4. customevacuated
  5. customBy recrystallization from acetic-acid/cyclohexane

Sources & evidence

ORD record
ord-0189d9366084400285d6da417753baa7
Source dataset
uspto-grants-1984_03
Patent number
US04435403

Reaction notes

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