HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 13136251, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 1,5-Diazabicyclo(5,4,0)undec-5-ene | HCID 314112 | — |
| Reactant | HCID 13136250 | HCID 13136250 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 13136251 | HCID 13136251 | 28.3% |
Reaction Steps
156 mg of 6-(3-chloro-1-propinyl)-beta-carboline-3-carboxylic-acid-ethylester is stirred together with 85 mg of piperidine and 76 mg of 1.5-diazabicyclo-[5.4.0]undec-5-ene in 10 ml of absolute ethanol under nitrogen and exclusion of water for 11/2 h at 60° C. After evaporation, the residue is chromatographed on 25 g of silica gel with methylene-chloride/methanol (10/2) as the eluant. 51 mg of 6-[3-(1-piperidinyl)-1-propinyl]-beta-carboline-3-carboxylic-acid-ethylester is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04435403 |
| Source dataset | uspto-grants-1984_03 |
| ORD ID | ord-e81c5445080e43c69ee592818c3377b3 |
| Source note | uspto-grants-1984_03 |