HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4-Dibromobutane → 6-(1-Pyrrolidinyl)-beta-carboline-3-carboxylic-acid-ethylester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4-Dibromobutane | HCID 8056 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Ethyl 6-amino-9H-beta-carboline-3-carboxylate | HCID 603089 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 6-(1-Pyrrolidinyl)-beta-carboline-3-carboxylic-acid-ethylester | HCID 13136252 | — |
Reaction Steps
383 mg of 6-amino-beta-carboline-3-carboxylic-acid-ethylester in 15 ml of ethanol is heated together with 0.58 ml of ethyldiisopropylamine and 0.18 ml of 1,4-dibromobutane for 6 h under nitrogen at the reflux. This is followed by an addition of 0.4 ml of 1,4-dibromobutane and reflux for 3 h. After evaporation, the mixture is washed with water and boiled with ethanol. 128 mg of 6-(1-pyrrolidinyl)-beta-carboline-3-carboxylic-acid-ethylester with a m.p. of 259°-261° C. is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04435403 |
| Source dataset | uspto-grants-1984_03 |
| ORD ID | ord-a84434b41cde4f079404c58987c00380 |
| Source note | uspto-grants-1984_03 |