Hydrochloric Acid → HCID 15614163, compound

Participants

Reaction Steps

A mixture of 11 g of the product of Step B and 600 ml of N hydrochloric acid was refluxed for 3 hours and was then cooled to 20°-25° C. Concentrated sodium hydroxide was added to the mixture to make it alkaline and the mixture was then saturated with potassium carbonate. The mixture was extracted with ethyl acetate and the organic phase was dried and evaporated to dryness. The 3.65 g of residue were chromatographed over silica gel and eluted with a 7-2-1 chloroform-methanol-triethylamine mixture to obtain 3.6 g of 1,3-dihydro-4-(piperidin-3-yl)-2H-indole-2-one.

Provenance & Evidence