HCID 53782960, compound → HCID 13288206, compound

Participants

Reaction Steps

Into 100 ml of ethanol were added 5 g of 6-{4-[N-(2-hydroxyethyl)-N-cyclohexylmethylaminocarbonyl]-2-butenyloxy}-3,4-dihydrocarbostyril and 1 g of 1% palladium-carbon. The mixture was catalytically hydrogenized under an atmospheric pressure at a room temperature for 5 hours. After the reaction was completed, the catalyst was removed by filtration and the filtrate was concentrated. The residue thus obtained was recrystallized from ethyl acetate-petraleum ether to obtain 4.2 g of 6-{4-[N-(2-hydroxyethyl)-N-cyclohexylmethylaminocarbonyl]butoxy}-3,4-dihydrocarbostyril as in the form of colorless plate-like crystals. Melting point: 123°-125° C.

Provenance & Evidence