Phosphorus oxychloride → 2,6-Dichloro-3-phenylquinoline

Participants

Reaction Steps

6-Chloro-3-phenylquinolin-2-one (6.7 gm.) and phosphorus oxychloride (100 ml.) were heated together under reflux for 2 hr. The reaction mixture was then poured into ice water (1000 ml.) and extracted with ethyl acetate (3×100 ml.). The ethyl acetate extract was washed with water (3×50 ml.) and dried (Na2SO4), and the solvent was evaporated. The resulting solid was crystallised from ethanol to give 2,6-dichloro-3-phenylquinoline, m.p. 147°-9°.

Provenance & Evidence