Thiourea → HCID 13200300, compound

Participants

Reaction Steps

A mixture of 2-chloro-3-(p-cyanophenyl)quinoline (6.25 g., see Example 30) and thiourea (1.8 g.) in ethanol (30 ml.) was heated under reflux for 2 hr. The solution was allowed to cool to ambient temperature, the solid which precipitated was filtered off, dispersed in 1 M-sodium hydroxide solution (100 ml.) and the dispersion heated on a steam bath for 20 min. The mixture was acidified with 2 M-hydrochloric acid solution. The resulting mixture was filtered, the solid residue was stirred with hot ethanol (75 ml.) for 5 min., and the mixture was then filtered. There was thus obtained as the solid residue 3-(p-cyanophenyl)quinolin-2-thione, m.p. 284°-9°.

Provenance & Evidence