Thiourea → HCID 13200303, compound

Participants

Reaction Steps

A mixture of 2-chloro-3-(p-fluorophenyl)quinoline (6.03 g., see Example 3) and thiourea (1.8 g.) in ethanol (30 ml.) was heated under reflux for 2 hr. The solution was allowed to cool to ambient temperature, the solid which precipitated was filtered off, dispersed in 1 M-sodium hydroxide solution (100 ml.), and the dispersion heated on a steam bath for 20 min. The mixture was acidified with 2 M-hydrochloric acid solution. The resulting mixture was filtered, the solid residue was stirred with hot ethanol (75 ml.) for 5 min., and then filtered. There was thus obtained as the solid residue 3-(p-fluorophenyl)quinolin-2-thione, m.p. 259°-262°.

Provenance & Evidence