HCID 54438806, compound → HCID 20468223, compound

Participants

Reaction Steps

2-(1-Butoxycarbonyl-3-piperidylthio)--3-phenylquinoline (4.2 g.) was added to 6 M-hydrogen chloride in ethyl acetate (50 ml.), and the mixture was stirred at ambient temperature for 1 hr. The solvent was evaporated and the residual oil was dissolved in diethyl ether (100 ml.) and extracted with 1 M-hydrochloric acid solution (20×30 ml.). The hydrochloric acid extract was adjusted to pH 10 with saturated sodium carbonate solution and extracted with diethyl ether (2×100 ml.). The diethyl ether extract was washed with brine (75 ml.) and then dried (MgSO4). The solvent was evaporated to give 3-phenyl-2-(3-piperidylthio)quinoline which was used without further purification.

Provenance & Evidence