HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1903248Generated: October 26, 2026
Hydrochloric Acid → 3-Amino-4,4-difluorobutanoic acid hydrochloride
https://huagongshe.com/reaction/1903248
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ethyl 3-amino-4,4-difluorobutanoate | HCID 20468444 | — |
| Product | 3-Amino-4,4-difluorobutanoic acid hydrochloride | HCID 71403098 | 80% |
Reaction Steps
Ethyl 4,4-difluoro-3-amino-butanoate prepared as in Step B (3.340 g, 20 mM) is dissolved in 1 M HCl (20 ml) and the mixture heated at 100° C. for 3 hours. The solvent is evaporated in vacuo. The oily residue is crystallized from ethanol/ether; 2.800 g of 4,4-difluoro-3-amino-butanoic acid, hydrochloride (yield 80%). Mp: 150° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04435425 |
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| Source dataset | uspto-grants-1984_03 |
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| ORD ID | ord-e92096add8f54b19b671f72cd9654322 |
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| Source note | uspto-grants-1984_03 |
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