HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bicifadine → 3-Cyclopropanecarbonyl-1-(p-tolyl)-3-azabicyclo[3.1.0]hexane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bicifadine | HCID 47953 | — |
| Reactant | Cyclopropanecarbonyl chloride | HCID 77637 | — |
| Product | 3-Cyclopropanecarbonyl-1-(p-tolyl)-3-azabicyclo[3.1.0]hexane | HCID 12891369 | — |
Reaction Steps
In a like manner 1-(p-tolyl)-3-azabicyclo[3.1.0]hexane (Example 32) is reacted with cyclopropanecarbonyl chloride to give 3-cyclopropanecarbonyl-1-(p-tolyl)-3-azabicyclo[3.1.0]hexane which is reduced as above to give 3-cyclopropylmethyl-1-(p-tolyl)-3-azabicyclo[3.1.0]hexane hydrochloride as colorless crystals, m.p. 180°-182° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04435419 |
| Source dataset | uspto-grants-1984_03 |
| ORD ID | ord-51df4622f3b347b897580bfd27f98e1e |
| Source note | uspto-grants-1984_03 |