HuagongsheHuagongshe Chemistry Print Report · For research reference only
Red-Al → 3-(p-Chlorobenzyl)-1-(p-chlorophenyl)-3-azabicyclo[3.1.0]hexane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Red-Al | HCID 16684438 | — |
| Reactant | (4-Chlorophenyl)[1-(4-chlorophenyl)-3-azabicyclo[3.1.0]hexan-3-yl]methanone | HCID 20468348 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 3-(p-Chlorobenzyl)-1-(p-chlorophenyl)-3-azabicyclo[3.1.0]hexane | HCID 13279021 | — |
Reaction Steps
A 16.60 g. portion of 3-(p-chlorobenzoyl)-1-(p-chlorophenyl)-3-azabicyclo[3.1.0]hexane is dissolved in 160 ml. of benzene and 55.5 g. of Vitride® is added dropwise. The mixture is refluxed for 2 hours, cooled and quenched slowly with 10 N sodium hydroxide. Water is added, the organic layer is separated and washed 3 times with water and then dried over magnesium sulfate. Removal of the solvent yields an off-white solid, m.p. 88°-92° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04435419 |
| Source dataset | uspto-grants-1984_03 |
| ORD ID | ord-748a451e77d9495bb7be7fb378e3d541 |
| Source note | uspto-grants-1984_03 |