反应详情

To 15.9 g. of 1-phenyl-3-azabicyclo[3.1.0]hexane in 20 ml. of pyridine is added 20 ml. of acetic anhydride. The mixture is allowed to stand overnight at room temperature and then evaporated to give an oil. This oil is dissolved in a mixture of ether and methylene chloride, washed with dilute hydrochloric acid and then sodium bicarbonate, dried over magnesium sulfate and evaporated to a pale amber liquid. This liquid is crystallized from hexane to give the product 3-acetyl-1-phenyl-3-azabicyclo[3.1.0]hexane, m.p. 63°-65° C.

1. customevaporated
2. customto give an oil
3. washwashed with dilute hydrochloric acid
4. dry with materialsodium bicarbonate, dried over magnesium sulfate
5. customevaporated to a pale amber liquid
6. customThis liquid is crystallized from hexane