HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3,6-Dimethyl-1-phenyl-3-azabicyclo[3.1.0]hexane hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Red-Al | HCID 16684438 | — |
| Reactant | N, 3-dimethylcyclopropane-1,2-dicarboximide | HCID 20468377 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 3,6-Dimethyl-1-phenyl-3-azabicyclo[3.1.0]hexane hydrochloride | HCID 20468395 | — |
Reaction Steps
To a stirred solution of N,3-dimethylcyclopropane-1,2-dicarboximide (U.S. Pat. No. 3,166,571, Ex. 2) in benzene is added Vitride® for several minutes. This solution is stirred at ambient temperature for several hours, refluxed for one hour, and then cooled and combined with sodium hydroxide and worked-up and converted to the hydrochloride to give the title product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04435419 |
| Source dataset | uspto-grants-1984_03 |
| ORD ID | ord-e2f9cb06bce747958e75bd3488e652ce |
| Source note | uspto-grants-1984_03 |