反应详情

In 40 ml of dry methanol were suspended 126 mg of 2-amino-5-aminomethylpyrrolo[2,3-d]pyrimidin-4-one (dihydrochloride) and 116 mg of p-iodobenzaldehyde. After addition of 1 N methanolic sodium methoxide, the mixture was stirred at room temperature for 30 min. To this mixture was added 76 mg of sodium borohydride and the reaction was conducted at room temperature for 15 min. The reaction was then terminated by addition of 500 mg silica gel. The solvent was distilled off under reduced pressure and the residue was purified by silica gel chromatography to give 121 mg of the desired compound.

1. waitthe reaction was conducted at room temperature for 15 min
2. customThe reaction was then terminated by addition of 500 mg silica gel
3. distillationThe solvent was distilled off under reduced pressure
4. customthe residue was purified by silica gel chromatography