Acetone → Urea, N-(1-methylethyl)-N'-phenyl-

HRID 1903288Notes

Reaction equation

HRID 1903288 reaction equation
[CH:1]([NH2:4])([CH3:3])[CH3:2].CC(C)=O.[SH2]=N.[C:11]1([NH:17][C:18](C2C=CC=CC=2C(O)=O)=[O:19])[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>O>[C:11]1([NH:17][C:18]([NH:4][CH:1]([CH3:3])[CH3:2])=[O:19])[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

Participants

5

Reactant 3

HCID 180Acetone2×HCID 6363IsopropylamineHCID 178514671HCID 178514671, compound

Product 1

HCID 29852Urea, N-(1-methylethyl)-N'-phenyl-Yield 81.4%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 0.75 g i-propylamine with 5 ml aceton was added dropwise to a suspension of 1,5 g phenylcarbamoyl-benzoic acid sulfimide with 10 ml acetone, under stirring. The reaction mixture was stirred for 30 minutes at ambient temperature, then diluted with 50 ml water and cooled. The 0.75 g crystalline 1-phenyl-3-i-propylurea was isolated by filtration (melting point: 158°-160° C.).

Workup

  1. stirringThe reaction mixture was stirred for 30 minutes at ambient temperature
  2. temperaturecooled

Sources & evidence

ORD record
ord-1fe8d554eae24ad7812cda8d61d52c80
Source dataset
uspto-grants-1984_03
Patent number
US04435567

Reaction notes

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