Hydrochloric Acid → HCID 13307165, compound

Participants

Reaction Steps

2.5 g of 2-methylamino-4-(N-formylpiperazino)-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidine obtained in Example 4, 50 ml of ethanol and 4 ml of concentrated hydrochloric acid were heated on a water bath for 2 hours. After cooling, water was added thereto, and the mixture was rendered alkaline with potassium carbonate and extracted with chloroform. The chloroform layer was washed with water and dried over magnesium sulfate. The solvent was distilled off and the residue was converted into the corresponding maleate in 50 ml of ethanol. The maleate was recrystallized from methanol-isopropyl alcohol to obtain 2.5 g of 2-methylamino-4-piperazino-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidine dimaleate as colorless needles having a melting point of 162°-165° C.

Provenance & Evidence